Benefits
- Repairs and regenerates skin at a cellular level
- Stimulates collagen and elastin production
- Improves skin texture and tone
- Deeply hydrates and plumps the skin
- Reduces fine lines and dark circles
Repair, regenerate, renew
Plinest Polynucleotide Skin Booster In York by Dr Katherine
Polynucleotides are a next-generation bio-stimulating skin booster derived from purified DNA fragments that work at a cellular level to repair, regenerate, and rejuvenate the skin — improving texture, hydration, and elasticity from within.
Polynucleotides at a Glance
A quick overview of our treatment benefits and expectations
Treatment Areas
- Face
- Under eyes (periorbital)
- Neck
- Décolletage
- Hands
Procedure
- Course of 2–3 sessions, 3–4 weeks apart
- Multiple micro-injections into the treatment area
- Appointments take approximately 30–45 minutes
Pain Level
- Minimal discomfort with topical anaesthetic
- Fine needles used for a comfortable experience
Downtime
- Minimal downtime
- Small bumps or redness at injection sites settle within a few hours
Results
- Gradual improvements throughout the course
- Optimal results visible around 4–8 weeks after completing the course
Duration
- Results typically last around 6–12 months
- Maintenance sessions recommended as needed
Costs
- Pricing depends on treatment areas and number of sessions
- Tailored recommendations provided at consultation
What Are Polynucleotides?
Cellular repair for visibly healthier skin
Polynucleotides (PNs) are purified fragments of DNA, typically derived from salmon or trout DNA, that act as powerful bio-stimulators when injected into the skin. Unlike traditional fillers or hyaluronic acid-based skin boosters, polynucleotides work at a cellular level to activate fibroblasts — the cells responsible for producing collagen, elastin, and other essential components of healthy skin.
The result is genuine skin regeneration — improved texture, increased hydration, enhanced elasticity, and a visible reduction in fine lines. Polynucleotides also have antioxidant and anti-inflammatory properties, making them particularly effective for damaged or ageing skin, including the delicate under-eye area.
At Aesthetics by Dr Katherine, polynucleotide treatments are administered with precision and care, tailored to your individual skin concerns and goals. Dr Katherine will assess your skin and recommend the most appropriate treatment plan during your consultation.
Did You Know?
Polynucleotides have been used in medicine for decades in wound healing and tissue repair. Their application in aesthetics harnesses the same regenerative science to rejuvenate skin at a deeper, cellular level — making them one of the most exciting advances in skin booster treatments.
Explore Our Doctor-Led Polynucleotide Treatments in York
Targeting the most common areas of concern
Following assessment, treatment may be offered where skin quality, texture, and regeneration can be improved
Face
Polynucleotide treatment can help to repair and regenerate skin on the face, improving texture, hydration, and elasticity for a naturally refreshed and youthful appearance.
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Under Eyes
Polynucleotides are particularly effective for the delicate periorbital area, helping to reduce dark circles, fine lines, and crepey skin whilst improving skin quality.
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Neck
Targets crepey texture and loss of elasticity in the neck, stimulating cellular repair for smoother, firmer skin.
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Hands
Rejuvenates the skin on the hands where thinning and dehydration can make skin look older than the face.
Book NowWhat to Expect During Treatment
1. Consultation & Assessment
Dr Katherine will assess your skin quality, discuss your concerns and goals, and determine whether polynucleotides are the most suitable treatment for you. A personalised treatment plan will be created.
2. Preparation
The treatment area is cleansed and topical anaesthetic cream is applied to ensure your comfort throughout the procedure.
3. Injection
Polynucleotides are administered via multiple small injections across the treatment area using fine needles. The product is distributed carefully to stimulate cellular repair and regeneration. The process is quick and well tolerated.
4. Aftercare
Dr Katherine will provide aftercare guidance. Small bumps or mild redness may be visible at injection sites but typically settle within a few hours. You can return to normal activities straight away.
5. Follow-Up Sessions
The standard polynucleotide protocol involves a course of 2–3 sessions spaced 3–4 weeks apart. Completing the full course is important for achieving optimal cellular regeneration and lasting results.
Recommended Treatment Schedule
Polynucleotide treatments are administered as a course of 2–3 sessions, spaced 3–4 weeks apart. This protocol allows the bio-stimulating formula to progressively activate fibroblasts and promote deep cellular regeneration with each session.
After completing the initial course, results typically last around 6–12 months depending on your skin’s response and lifestyle factors. Maintenance sessions can be arranged to sustain the improvements in skin quality, texture, and elasticity.
Dr Katherine will advise on the ideal schedule based on your skin’s response and your individual goals.
Treatment Timeline
Session 1
Initial polynucleotide treatment to begin cellular regeneration
3–4 Weeks
Follow-up session(s) to build on results and deepen regeneration
4–8 Weeks After Course
Optimal results visible — improved texture, hydration, and elasticity
Every 6–12 Months
Maintenance sessions to sustain skin quality improvements
Am I a Good Candidate for Polynucleotides?
Polynucleotide treatments are suitable for most adults looking to improve overall skin quality, texture, and elasticity through deep cellular regeneration.
You May Be a Good Candidate If You:
- Notice dull, dehydrated, or tired-looking skin
- Have dark circles or fine lines around the eyes
- Have fine lines or loss of skin elasticity
- Want to improve skin texture and tone
- Are looking for deep skin regeneration without volume
- Are in good general health
Treatment May Not Be Suitable If You:
- Are pregnant or breastfeeding
- Have active skin infection in the treatment area
- Have a known allergy to any of the ingredients
- Have certain autoimmune conditions
A full consultation with Dr Katherine will confirm whether polynucleotides are right for you.
Aftercare Guidelines
Following these simple aftercare instructions will help ensure optimal results.
Do
- Stay well hydrated
- Allow any small bumps to settle naturally
- Resume your normal skincare routine after 24 hours
- Contact Dr Katherine if you have any concerns
Don't
- Touch or massage the treated area for 24 hours
- Exercise vigorously for 24 hours
- Apply makeup for at least 6 hours
- Use saunas or sunbeds for 48 hours
- Consume excessive alcohol for 24 hours
Why Choose Aesthetics By Dr Katherine?
Excellence in Every Detail
Medical Expertise
All treatments are performed by qualified & experienced medical doctor with specialist training in regenerative treatments.
Natural Results
Our philosophy focuses on enhancing your natural beauty with subtle, elegant outcomes.
Safety First
Premium products, sterile techniques, and comprehensive aftercare for your peace of mind.
Bespoke Approach
Personalised treatment plans designed specifically for your unique facial structure and goals.
Patient Testimonials
What Our Clients Say
Frequently Asked Questions
Polynucleotides work differently from hyaluronic acid-based skin boosters like Profhilo. While Profhilo deeply hydrates and stimulates collagen through hyaluronic acid, polynucleotides use purified DNA fragments to activate fibroblasts at a cellular level, promoting genuine tissue repair and regeneration. They also have anti-inflammatory and antioxidant properties. Dr Katherine can advise which skin booster is most suitable for your concerns during consultation.
Most patients find the treatment very comfortable. Topical anaesthetic cream is applied before treatment, and fine needles are used to minimise discomfort. A brief, mild pinching sensation may be felt at each injection point, but the procedure is quick and well tolerated.
The standard protocol involves a course of 2–3 treatment sessions spaced 3–4 weeks apart. Completing the full course is important for achieving optimal regenerative results. Maintenance sessions can then be arranged as needed to sustain improvements.
Some patients notice improvements in skin hydration and quality during the course of treatment. However, the full regenerative effects — including improved texture, elasticity, and skin quality — are typically visible around 4 to 8 weeks after completing the course, as collagen and elastin production increases over time.
Downtime is minimal. Small bumps or mild redness may appear at injection sites but usually settle within a few hours. Mild bruising can occasionally occur but resolves quickly. Most patients return to normal activities straight away.
Yes. Polynucleotides work well alongside other treatments such as anti-wrinkle injections, dermal fillers, Profhilo, and Sunekos. Dr Katherine can advise on the best combination and timing to complement your overall aesthetic goals.
Yes. Polynucleotide treatments have a strong safety profile and have been used in regenerative medicine for many years. The DNA fragments are highly purified and biocompatible. As with any injectable treatment, potential risks and side effects are discussed in detail during your consultation to ensure you are fully informed.
Have more questions?
Get In TouchReady to Regenerate Your Skin from Within?
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